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KMID : 0378019930360030059
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New Medical Journal
1993 Volume.36 No. 3 p.59 ~ p.64
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Clinical Efficacy of Pravastatin (Mevalotin^(®)) in Patients with Hypercholesterolemia
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Abstract
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We studied the effects and side effects of the HMG-CoA reductase inhibitor, pravastatin (Mevalotin®) in 30 patients with hypercholesterolemia Mean age of the subjects was 58 years with range of 37 to 78 years.
There were 12 cases of male and 18 cases of female.
The 10mg of pravastatin was given and serum total cholesterol, HDL-cholesterol, triglyceride were measured before and after medication in every 2 weeks for the period of 8 weeks.
The following results were observed ;
1. Total cholesterol level was significantly decreased from 280±37mg% to 208±31% (26%, p<0.005).
2. Triglyceride level was significantly decreased from 287±179mg% to 212±105mg% (25%, p<0.005).
3. HDL-cholesterol level was not significantly changed (51 ± 13mg%-+49± 12mg%, p= N.S).
4. LDL-cholesterol level was significantly decreased from 173±39mg% to 117±24mg% (32%, p<0.005).
5. No serious side effects and significant changes of laboratory results (liver function test, blood glucose, creatine phosphokinase, lactic dehydrogenase) were found.
In conclusion, the pravastatin is an effective and safe lipid lowering agent.
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KEYWORD
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